Isoprostane, an “Intermediate Phenotype” for Oxidative Stress
نویسندگان
چکیده
منابع مشابه
Isoprostane, an "intermediate phenotype" for oxidative stress heritability, risk trait associations, and the influence of chromogranin B polymorphism.
OBJECTIVES The purpose of this study is to understand whether isoprostane, a biomarker of oxidative stress, is subject to heritable control; whether it shares heritability with other cardiometabolic risk traits; and finally whether genetic variation at a specific candidate locus contributes to isoprostane variability. BACKGROUND Isoprostane marks oxidative stress, and elevated isoprostane exc...
متن کامل8-isoprostane as Oxidative Stress Marker in Coal Mine Workers.
This study was to investigate whether working in conditions of elevated concentrations of mine gases (CO2, CO, CH4, DMS) and dust may result in oxidative stress. Coal miners (n=94) from the Velenje Coal mine who were arranged into control group and three groups according to a number of consecutive working days. 8-isoprostane as a biological marker of oxidative stress was measured in exhaled bre...
متن کاملOxidative stress and vascular disease: insights from isoprostane measurement.
Over the last 20 years, overwhelming evidence has accumulated indicating that oxidation of lipoproteins plays an important role in the development of atherosclerosis (1 ). The pathophysiology of atherosclerosis is characterized by two key processes, lipid deposition and inflammation, within the arterial wall, and oxidative stress provides a link between the two (2 ). Despite general acceptance ...
متن کاملMajor metabolite of F2-isoprostane in urine may be a more sensitive biomarker of oxidative stress than isoprostane itself.
BACKGROUND There is limited literature on the contributors to isoprostane metabolite 2,3-dinor-5,6-dihydro-15-F(2t)-isoprostane (15-F(2t)-IsoP-M) compared with F(2)-isoprostanes (F(2)-IsoPs) as an oxidative stress biomarker. OBJECTIVE The objective of this study was to investigate whether plasma concentrations of antioxidants, urinary excretion rates of polyphenols, and antioxidants in food a...
متن کاملAngioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA.
OBJECTIVES Isoprostanes, stable end-products of oxygen free radical mediated-lipid peroxidation, were measured in the coronary vessels during percutaneous transluminal coronary angioplasty (PTCA) to provide direct evidence for enhanced oxidative stress in a local milieu in vivo. BACKGROUND Percutaneous transluminal coronary angioplasty is associated with complications such as myocardial stunn...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2010
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2010.03.092